Gastric cancer is the second leading cause of cancer death worldwide. Compared with other malignancies, gastric cancer has a relatively low incidence in the United States but the mortality rate remains high. In the Western world, the majority of gastric cancer diagnoses are made at an advanced stage in which either the tumor is inoperable or has a high chance of recurrence following surgical resection. Chemotherapy has a well-defined role in the treatment of patients with advanced gastric cancer, but recent increases in knowledge regarding the molecular mechanisms that drive gastric carcinogenesis may offer some patients new therapeutic options.
This educational activity will increase learners’ knowledge of the current understanding of tumor biology, risk factors, and management of gastric cancer as well as the rationale for and mechanisms of action of molecularly targeted agents currently approved or under investigation for the treatment of advanced gastric cancer. Additionally, this online publication features expert discussion of a realistic, clinical case designed to provide information immediately applicable to clinical practice. Corresponding faculty discussion has been captured to provide expert perspective regarding current clinical evidence and treatment options.